The role of type 2 diabetes in neurodegeneration
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
The link between type 2 diabetes and neurodegeneration: roles for amyloid-β, amylin, and tau proteins
P Bharadwaj, N Wijesekara… - Journal of …, 2017 - content.iospress.com
A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and
neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise …
neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise …
[HTML][HTML] Is Alzheimer's disease a systemic disease?
Although Alzheimer's disease (AD) is the most common neurodegenerative disease, the
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …
etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a …
LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-
beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate …
beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate …
[HTML][HTML] Nicotinamide mononucleotide: exploration of diverse therapeutic applications of a potential molecule
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as
an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. Although the …
an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. Although the …
[HTML][HTML] Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics
WF Goure, GA Krafft, J Jerecic, F Hefti - Alzheimer's research & therapy, 2014 - Springer
Levels of amyloid-beta monomer and deposited amyloid-beta in the Alzheimer's disease
brain are orders of magnitude greater than soluble amyloid-beta oligomer levels. Monomeric …
brain are orders of magnitude greater than soluble amyloid-beta oligomer levels. Monomeric …
Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
AJ Hinrich, FM Jodelka, JL Chang… - EMBO molecular …, 2016 - embopress.org
Abstract Apolipoprotein E receptor 2 (Apo ER 2) is an apolipoprotein E receptor involved in
long‐term potentiation, learning, and memory. Given its role in cognition and its association …
long‐term potentiation, learning, and memory. Given its role in cognition and its association …
Intracellular accumulation of amyloid-β (Aβ) protein plays a major role in Aβ-induced alterations of glutamatergic synaptic transmission and plasticity
C Ripoli, S Cocco, DDL Puma, R Piacentini… - Journal of …, 2014 - Soc Neuroscience
Intracellular accumulation of amyloid-β (Aβ) protein has been proposed as an early event in
AD pathogenesis. In patients with mild cognitive impairment, intraneuronal Aβ …
AD pathogenesis. In patients with mild cognitive impairment, intraneuronal Aβ …
Age‐dependent impairment of glucose tolerance in the 3xTg‐AD mouse model of Alzheimer's disease
Alzheimer's disease (AD) has been associated with type II diabetes (T2D) and obesity in
several epidemiologic studies. To determine whether AD neuropathology can cause …
several epidemiologic studies. To determine whether AD neuropathology can cause …
Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies
K Xhima, K Markham-Coultes, R Hahn Kofoed… - Brain, 2022 - academic.oup.com
Early degeneration of basal forebrain cholinergic neurons contributes substantially to
cognitive decline in Alzheimer's disease. Evidence from preclinical models of neuronal …
cognitive decline in Alzheimer's disease. Evidence from preclinical models of neuronal …