[PDF][PDF] Maternal inflammation and its ramifications on fetal neurodevelopment
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …
inflammatory insults has been associated with the onset of neurodevelopmental and …
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …
gut microbiota is a key player in communication between these two distant organs. Yet, the …
Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles
BM Tijms, EM Vromen, O Mjaavatten, H Holstege… - Nature aging, 2024 - nature.com
Alzheimer's disease (AD) is heterogenous at the molecular level. Understanding this
heterogeneity is critical for AD drug development. Here we define AD molecular subtypes …
heterogeneity is critical for AD drug development. Here we define AD molecular subtypes …
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
[HTML][HTML] A cellular and spatial map of the choroid plexus across brain ventricles and ages
The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus
Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of
cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An …
cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An …
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …
macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune …
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain
Germinal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition
affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture …
affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture …
The choroid plexus: a missing link in our understanding of brain development and function
NR Saunders, KM Dziegielewska… - Physiological …, 2023 - journals.physiology.org
Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …
despite a much longer history. This review has two overall aims. The first is to outline long …
Modulation of cerebrospinal fluid dysregulation via a SPAK and OSR1 targeted framework nucleic acid in hydrocephalus
Q Wang, J Cheng, F Liu, J Zhu, Y Li, Y Zhao… - Advanced …, 2024 - Wiley Online Library
Hydrocephalus is one of the most common brain disorders and a life‐long incurable
condition. An empirical “one‐size‐fits‐all” approach of cerebrospinal fluid (CSF) shunting …
condition. An empirical “one‐size‐fits‐all” approach of cerebrospinal fluid (CSF) shunting …