The linear no-threshold (LNT) model is currently used to estimate low dose radiation (LDR)
induced health risks. This model lacks safety thresholds and postulates that health risks …

This review article provides a comprehensive overview of the experimental data detailing
the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS) …

The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While
DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA …

Cancer risk and radiation sensitivity are often associated with alterations in DNA repair, cell
cycle, or apoptotic pathways. Interindividual variability in mutagen or radiation sensitivity and …

Modern models of radiobiological effects include mechanisms of damage initiation, sensing
and repair, for those cells that directly absorb ionizing radiation as well as those that …

Over the past several years, investigations in both low-dose hyper-radiosensitivity and
increased radioresistance have been a focus of radiation oncology and biology research …

Purpose: Prostate-specific membrane antigen (PSMA) targeting therapies such as Lutetium-
177 (177Lu)–PSMA-617 are affecting outcomes from metastatic castration-resistant prostate …

Background DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype
and high-frequency microsatellite instability (MSI-H), which are the hallmarks of many …

Low dose hyper-radiosensitivity and induced radioresistance are primarily observed in
surviving fractions of cell populations exposed to ionizing radiation, plotted as the function of …

Abstract The DNA Mismatch Repair (MMR) pathway is a fundamental cellular process
required to repair mispaired bases introduced routinely during DNA replication. Given this …