DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

Reproduction in most fish is seasonal or periodic, and the spawning occurs in an
appropriate season to ensure maximum survival of the offspring. The sequence of …

Background Melatonin, an indoleamine produced by the pineal gland, plays a pivotal role in
maintaining circadian rhythm homeostasis. Recently, the strong antioxidant and anti …

Pinealectomy in vertebrates accelerated intervertebral disk degeneration (IDD). However,
the potential mechanisms, particularly melatonin's role, are still to be clarified. In this study …

As one of the leading cases of acute liver failure triggered by excessive Acetaminophen
(APAP), breakdown of the antioxidant system, inflammatory response, and inescapable …

The beneficial effect of Melatonin (Mel), recognized as an anti-inflammatory and antioxidant
compound, has been already proven to prevent oxidative stress-induced damage …

Microglia activation and associated inflammatory response play pivotal roles in the
pathogenesis of different neurodegenerative diseases including neonatal hypoxic brain …

Key message Ectopic expression of MmCYP1A1 gene from Mus musculus in apple calli and
Arabidopsis increased the levels of melatonin and 6-hydroxymelatonin, and improved their …

This study examined particularly relevant redox pathways such as glycolysis, pentose
phosphate pathway (PPP), metHb reductase and nucleotide metabolism, in order to better …

This study aimed to establish the importance of ergothioneine (ERT) in the erythroid
adaptation mechanisms by appraising the expression levels of redox-related genes …