The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

Computational fluid dynamics (CFD) is one of the most emerging fields of fluid mechanics
used to analyze fluid flow situation. This analysis is based on simulations carried out on …

Top-down ultraviolet photodissociation (UVPD) allows greater sequence coverage than any
other currently available method, often fracturing the vast majority of peptide bonds in whole …

The extent to which noncovalent protein complexes retain native structure in the gas phase
is highly dependent on experimental conditions. Energetic collisions with background gas …

Protein–protein interfaces and architecture are critical to the function of multiprotein
complexes. Mass spectrometry-based techniques have emerged as powerful strategies for …

The growing interest in advancing tandem mass spectrometry strategies for top-down
proteomics has motivated efforts to optimize ion activation strategies for intact proteins …

Top-down proteomics studies intact proteoform mixtures and offers important advantages
over more common bottom-up proteomics technologies, as it avoids the protein inference …

The initial stages of protein unfolding may reflect the stability of the entire fold and can also
reveal which parts of a protein can be perturbed, without restructuring the rest. In this work …

The semiempirical orthogonalization-corrected OMx methods have recently been shown to
perform well in extensive ground-state benchmarks. They can also be applied to the …