Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Conditions that sustain constant bacterial growth are seldom found in nature. Oligotrophic
environments and competition among microorganisms force bacteria to be able to adapt …

Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and
survive these stresses, bacteria have global response systems that result in sweeping …

The traditional view of the stationary phase of the bacterial life cycle, obtained using
standard laboratory culture practices, although useful, might not always provide us with the …

Pseudomonas aeruginosa infections can be virtually impossible to eradicate, and the
evolution of resistance during antibiotic therapy is a significant concern. In this study, we use …

Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …

The global tuberculosis (TB) control effort is focused on interrupting transmission of the
causative agent, Mycobacterium tuberculosis, through chemotherapeutic intervention in …

Colony phase variation is a regulatory mechanism at the DNA level which usually results in
high frequency, reversible switches between colonies with a different phenotype. A number …

In some enterobacterial pathogens, but not in Escherichia coli, loss-of-function mutations are
a common route to clinically relevant β-lactam antibiotic resistance. We previously …