Digital imaging in pathology has undergone an exponential period of growth and expansion
catalyzed by changes in imaging hardware and gains in computational processing. Today …

As a review for the 20th anniversary of publishing the antigen retrieval (AR) technique in this
journal, the authors intend briefly to summarize developments in AR-immunohistochemistry …

Objectives The interaction between the immune system and tumor cells is an important
feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) …

Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as
part of the diagnostic workup for the majority of solid tissue malignancies. Existing IHC …

Antibody conjugates are widely used as diagnostics and imaging reagents. However, many
such conjugates suffer losses in sensitivity and specificity due to nonspecific labeling …

Objectives To evaluate the current evidence in relation to the predictive value of p53
overexpression as a biomarker of the malignant transformation risk in oral potentially …

Rationale: The relevance of hormones in idiopathic pulmonary fibrosis (IPF), a
predominantly male lung disease, is unknown. Objectives: To determine whether the ER …

Detection of biomolecules in tissues provides contextual information and the possibility to
assess the interaction of different cell types and markers. Routine qualitative assessment of …

A key reason for the persistently grim statistics associated with metastatic ovarian cancer is
resistance to conventional agents, including platinum-based chemotherapies. A major …

Antibodies play a crucial role in basic research and clinical decision-making. However, there
are no standardized algorithms or guidelines to ensure their accuracy and validity. There …