Immunotherapy shows efficacy for multiple cancer types and potential for expanded use.
However, current immune checkpoint inhibitors (ICIs) are ineffective against microsatellite …

Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold
hopping, isosteric replacement, high-throughput screening, induction and separation of …

The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …

The tumor microenvironment (TME) considerably influences colorectal cancer (CRC)
progression, therapeutic response and clinical outcome, but studies of interindividual …

The integration of quantitative trait loci (QTL) with disease genome-wide association studies
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …

The availability of patient cohorts with several types of omics data opens new perspectives
for exploring the disease's underlying biological processes and developing predictive …

Genome-wide association studies (GWAS) have identified more than 200 common genetic
variants independently associated with colorectal cancer (CRC) risk, but the causal variants …

Background While circulating metabolites have been increasingly linked to cancer risk, the
causality underlying these associations remains largely uninterrogated. Methods We …

Background Transcriptome-wide association studies have been successful in identifying
candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene …

This study aims to identify colorectal cancer (CRC)-related proteomic profiles and develop a
prediction model for CRC onset by integrating proteomic profiles with genetic and non …