Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

There is a growing realisation that the gut–brain axis and its regulation by the microbiota
may play a key role in the biological and physiological basis of neurodevelopmental, age …

The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …

Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

By 2050, the aging population is predicted to expand by over 100%. Considering this rapid
growth, and the additional strain it will place on healthcare resources because of age …

Over the last decade the important concept has emerged that microglia, similar to other
tissue macrophages, assume different phenotypes and serve several effector functions …

Astrocytes extend endfeet that enwrap the vasculature, and disruptions to this association
which may occur in disease coincide with breaches in blood-brain barrier (BBB) integrity …