Burden of community-acquired pneumonia and unmet clinical needs
J Ferreira-Coimbra, C Sarda, J Rello - Advances in therapy, 2020 - Springer
Community-acquired pneumonia (CAP) is the leading cause of death among infectious
diseases and an important health problem, having considerable implications for healthcare …
diseases and an important health problem, having considerable implications for healthcare …
Azithromycin: mechanisms of action and their relevance for clinical applications
MJ Parnham, VE Haber… - Pharmacology & …, 2014 - Elsevier
Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …
one in four deaths worldwide and are important causes of long-term functional disability …
Mechanisms of action and clinical application of macrolides as immunomodulatory medications
S Kanoh, BK Rubin - Clinical microbiology reviews, 2010 - Am Soc Microbiol
Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …
Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia
Objective To assess the effect on survival of macrolides or fluoroquinolones in intubated
patients admitted to the intensive care unit (ICU) with severe community-acquired …
patients admitted to the intensive care unit (ICU) with severe community-acquired …
Macrolides and mortality in critically ill patients with community-acquired pneumonia: a systematic review and meta-analysis
Objective: Some studies suggest better outcomes with macrolide therapy for critically ill
patients with community-acquired pneumonia. To further explore this, we performed a …
patients with community-acquired pneumonia. To further explore this, we performed a …
Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia
Importance Although clinical practice guidelines recommend combination therapy with
macrolides, including azithromycin, as first-line therapy for patients hospitalized with …
macrolides, including azithromycin, as first-line therapy for patients hospitalized with …
Pneumonia in low and middle income countries: progress and challenges
Pneumonia remains the leading cause of childhood mortality and the most common reason
for adult hospitalisation in low and middle income countries, despite advances in …
for adult hospitalisation in low and middle income countries, despite advances in …
Pneumonia as a cardiovascular disease
MI Restrepo, LF Reyes - Respirology, 2018 - Wiley Online Library
Community‐acquired pneumonia (CAP) is an important cause of death around the globe.
Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (ie …
Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (ie …
Community-acquired pneumonia in elderly patients
Community-acquired pneumonia continues to have a significant impact on elderly
individuals, who are affected more frequently and with more severe consequences than …
individuals, who are affected more frequently and with more severe consequences than …