Burden of community-acquired pneumonia and unmet clinical needs

J Ferreira-Coimbra, C Sarda, J Rello - Advances in therapy, 2020 - Springer
Community-acquired pneumonia (CAP) is the leading cause of death among infectious
diseases and an important health problem, having considerable implications for healthcare …

Azithromycin: mechanisms of action and their relevance for clinical applications

MJ Parnham, VE Haber… - Pharmacology & …, 2014 - Elsevier
Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

A Zumla, M Rao, RS Wallis, SHE Kaufmann… - The Lancet Infectious …, 2016 - thelancet.com
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

Mechanisms of action and clinical application of macrolides as immunomodulatory medications

S Kanoh, BK Rubin - Clinical microbiology reviews, 2010 - Am Soc Microbiol
Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia

I Martin-Loeches, T Lisboa, A Rodriguez… - Intensive care …, 2010 - Springer
Objective To assess the effect on survival of macrolides or fluoroquinolones in intubated
patients admitted to the intensive care unit (ICU) with severe community-acquired …

Macrolides and mortality in critically ill patients with community-acquired pneumonia: a systematic review and meta-analysis

WI Sligl, L Asadi, DT Eurich, L Tjosvold… - Critical care …, 2014 - journals.lww.com
Objective: Some studies suggest better outcomes with macrolide therapy for critically ill
patients with community-acquired pneumonia. To further explore this, we performed a …

Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia

EM Mortensen, EA Halm, MJ Pugh, LA Copeland… - Jama, 2014 - jamanetwork.com
Importance Although clinical practice guidelines recommend combination therapy with
macrolides, including azithromycin, as first-line therapy for patients hospitalized with …

Pneumonia in low and middle income countries: progress and challenges

HJ Zar, SA Madhi, SJ Aston, SB Gordon - Thorax, 2013 - thorax.bmj.com
Pneumonia remains the leading cause of childhood mortality and the most common reason
for adult hospitalisation in low and middle income countries, despite advances in …

Pneumonia as a cardiovascular disease

MI Restrepo, LF Reyes - Respirology, 2018 - Wiley Online Library
Community‐acquired pneumonia (CAP) is an important cause of death around the globe.
Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (ie …

Community-acquired pneumonia in elderly patients

JE Stupka, EM Mortensen, A Anzueto, MI Restrepo - Aging health, 2009 - Taylor & Francis
Community-acquired pneumonia continues to have a significant impact on elderly
individuals, who are affected more frequently and with more severe consequences than …