The development of technologies for the efficient synthesis of innovative antiviral
compounds remains an important challenge for modern biotechnology, especially in the …

Glycosyltransferases (GTs) are well-characterized with respect to static 3D structures and
molecular dynamics simulations, but there is a lack of reports on in-solution dynamics on …

This study evaluated 15 lactic acid bacteria with a focus on their ability to degrade inosine
and hypo-xanthine—which are the intermediates in purine metabolism—for the …

Over 70 million people are currently at risk of developing Chagas Disease (CD) infection,
with more than 8 million people already infected worldwide. Current treatments are limited …

Chagas disease (CD) is a parasitic disease endemic in several developing countries.
According to the World Health Organization, approximately 6-8 million people worldwide are …

Some copper (II) and zinc (II) complexes with oxindolimine ligands were tested regarding
their trypanocidal properties. These complexes have already shown good biological activity …

Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase (Pf
HGXPRT) is essential for purine salvage of hypoxanthine into parasite purine nucleotides …

Phosphate groups play essential roles in biological processes, including retention inside
biological membranes. Phosphodiesters link nucleic acids, and the reversible transfer of …

寄生原虫是一类单细胞寄生性原虫, 包括利什曼原虫(Leishmania spp.), 锥虫(Trypanosoma
spp.), 疟原虫(Plasmodium spp.), 刚地弓形虫(Toxoplasma gondii), 隐孢子虫(Cryptosporidium …

Natural products, and phytochemicals in particular, constitute a huge potential for drug
discovery and medical use against parasitic diseases. Novel drugs and safer and more …