Nowadays, it is impossible to imagine modern cancer treatment without targeted therapies,
such as mAbs, that bind to tumor-associated antigens. Subsequently, mAbs can use a wide …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by extensive
synovitis resulting in erosions of articular cartilage and marginal bone that lead to joint …

Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease
most prevalent in women. The true etiology of this disease is complex, multifactorial, and is …

Background Rheumatoid arthritis is characterized by the production of eicosanoids,
cytokines, adhesion molecules, infiltration of T and B lymphocytes in the synovium and …

Macrophages are highly plastic immune cells that dynamically integrate microenvironmental
signals to shape their own functional phenotypes, a process known as polarization. Here we …

Gliomas, including brain lower grade glioma (LGG) and glioblastoma multiforme (GBM), are
the most common primary brain tumors in the central nervous system. Neuregulin (NRG) …

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that imposes a
heavy economic burden on patients and society. Bone and cartilage destruction is …

Colorectal cancer (CRC) is a growing concern due to its high morbidity and mortality, and
the search for effective and less toxic active substances against inflammatory bowel …

Macrophages respond to signals in the microenvironment by changing their functional
phenotypes, a process known as polarization. Depending on the context, they acquire …

Most tumours are heavily infiltrated by immune cells. This has been correlated with either a
good or a bad patient prognosis, depending on the (sub) type of immune cells …