Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Stem cells have the ability to self-renew and differentiate along multiple lineages, driving
tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …

Organoids represent both a potentially powerful tool for the study cell-cell interactions within
tissue-like environments, and a platform for tissue regenerative approaches. The …

Epithelial barriers are programmed for defense and repair but are also the site of long-term
structural remodeling and disease. In general, this paradigm features epithelial stem cells …

Epithelial cells are charged with protection at barrier sites, but whether this normally
beneficial response might sometimes become dysfunctional still needs definition. Here, we …

The p38α mitogen‐activated protein kinase pathway not only regulates the production of
inflammatory mediators, but also controls processes related to tissue homeostasis, such as …

Cutaneous ageing is an important extrinsic process that modifies the pigmentary system.
Because cellular senescence is a fundamental ageing mechanism, we examined the role of …

Influenza Virus (IV) pneumonia is associated with severe damage of the lung epithelium and
respiratory failure. Apart from efficient host defense, structural repair of the injured epithelium …