Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …