Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

The central nervous system (CNS) and its meningeal coverings accommodate a diverse
myeloid compartment that includes parenchymal microglia and perivascular macrophages …

The central nervous system (CNS) is an immunologically specialized tissue protected by a
blood–brain barrier. The CNS parenchyma is enveloped by a series of overlapping …

Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the …

Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of
neutrophils. MPO utilizes H 2 O 2 to generate hypochlorous acid (HClO) and other reactive …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

A major function of T helper (Th) 17 cells is to induce the production of factors that activate
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …

Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory
insult, yet the molecular mechanism is still unknown. Here, we demonstrated that MC …

Neutrophil granulocyte biology is a central issue of immunological research, but the lack of
animal models that allow for neutrophil-selective genetic manipulation has delayed …