Meiosis: dances between homologs

D Zickler, N Kleckner - Annual Review of Genetics, 2023 - annualreviews.org
The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Recombination, pairing, and synapsis of homologs during meiosis

D Zickler, N Kleckner - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Recombination is a prominent feature of meiosis in which it plays an important role in
increasing genetic diversity during inheritance. Additionally, in most organisms …

Accessorizing and anchoring the LINC complex for multifunctionality

W Chang, HJ Worman, GG Gundersen - Journal of Cell Biology, 2015 - rupress.org
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner
nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 …

Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges

DA Starr, HN Fridolfsson - Annual review of cell and …, 2010 - annualreviews.org
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

RJ Wellinger, VA Zakian - Genetics, 2012 - academic.oup.com
The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

The nuclear envelope in genome organization, expression and stability

K Mekhail, D Moazed - Nature reviews Molecular cell biology, 2010 - nature.com
Non-random positioning of chromosomal domains relative to each other and to nuclear
landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA …

A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton

HF Horn, DI Kim, GD Wright, ESM Wong… - Journal of Cell …, 2013 - rupress.org
Chromosome pairing is an essential meiotic event that ensures faithful haploidization and
recombination of the genome. Pairing of homologous chromosomes is facilitated by …

Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia

C Xie, W Wang, C Tu, L Meng, G Lu… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

Meiosis: an overview of key differences from mitosis

H Ohkura - Cold Spring Harbor Perspectives in Biology, 2015 - cshperspectives.cshlp.org
Meiosis is the specialized cell division that generates gametes. In contrast to mitosis,
molecular mechanisms and regulation of meiosis are much less understood. Meiosis shares …

Meiosis in budding yeast

GV Börner, A Hochwagen, AJ MacQueen - Genetics, 2023 - academic.oup.com
Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …