Advances in xanthan gum-based systems for the delivery of therapeutic agents

M Jadav, D Pooja, DJ Adams, H Kulhari - Pharmaceutics, 2023 - mdpi.com
In the last three decades, polymers have contributed significantly to the improvement of drug
delivery technologies by enabling the controlled and sustained release of therapeutic …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

The knowns and unknowns of cardiac autoimmunity in viral myocarditis

K Mone, J Reddy - Reviews in Medical Virology, 2023 - Wiley Online Library
Myocarditis can result from various infectious and non‐infectious causes that can lead to
dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are …

Analytical performance specifications for measurement uncertainty in therapeutic monitoring of immunosuppressive drugs

D Cattaneo, M Panteghini - Clinical Chemistry and Laboratory …, 2024 - degruyter.com
The measurement uncertainty (MU) estimates and the definition of its maximum allowable
limits for the clinical application of measurements represents one of the mainstays to …

Molecular Mechanisms Responsible for the Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Lung Fibrosis

CR Harrell, V Djonov, A Volarevic… - International journal of …, 2024 - mdpi.com
Mesenchymal stem cell-derived exosomes (MSC-Exos) are nano-sized extracellular
vesicles which contain various MSC-sourced anti-fibrotic, immunoregulatory and angio …

Immunosuppressive strategies in face and hand transplantation: A comprehensive systematic review of current therapy regimens and outcomes

L Huelsboemer, S Boroumand, A Kochen… - Frontiers in …, 2024 - frontiersin.org
Background Recipients of Vascularized Composite Allotransplants require effective
immunosuppressive therapy to prevent graft rejection. This systematic review summarizes …

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

L Knoedler, J Dean, F Diatta, N Thompson… - Frontiers in …, 2024 - frontiersin.org
Balancing the immune response after solid organ transplantation (SOT) and vascularized
composite allotransplantation (VCA) remains an ongoing clinical challenge. While …

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals—a PARC (Partnership for the Assessment of Risk …

I Snapkow, NM Smith, E Arnesdotter… - Frontiers in …, 2024 - frontiersin.org
As a complex system governing and interconnecting numerous functions within the human
body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals …

The Effects of Chronic Immunosuppressive Treatment on Morphological Changes in Cardiac Tissue and the Balance between Matrix Metalloproteinases (MMP-2 and …

A Surówka, M Żołnierczuk, P Prowans… - International Journal of …, 2024 - mdpi.com
Using different three-drug immunosuppressive treatment regimens in a rat model, we aimed
to determine the effects of long-term therapy on metalloproteinase-2 and metalloproteinase …

Approaches Towards Better Immunosuppressive Agents

J Walczak, D Iwaszkiewicz-Grześ… - Current Topics in …, 2024 - ingentaconnect.com
Several classes of compounds are applied in clinics due to their immunosuppressive
properties in transplantology and the treatment of autoimmune diseases. Derivatives of …