Microtubule dynamics: an interplay of biochemistry and mechanics

GJ Brouhard, LM Rice - Nature reviews Molecular cell biology, 2018 - nature.com
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Control of microtubule organization and dynamics: two ends in the limelight

A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Up in the air: oxygen tolerance in controlled/living radical polymerisation

J Yeow, R Chapman, AJ Gormley… - Chemical Society Reviews, 2018 - pubs.rsc.org
The requirement for deoxygenation in controlled/living radical polymerisation (CLRP) places
significant limitations on its widespread implementation by necessitating the use of large …

Mitotic spindle assembly in animal cells: a fine balancing act

SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Anion recognition strategies based on combined noncovalent interactions

P Molina, F Zapata, A Caballero - Chemical Reviews, 2017 - ACS Publications
This review highlights the most significant examples of an emerging field in the design of
highly selective anion receptors. To date, there has been remarkable progress in the binding …

Nonequilibrium physics in biology

X Fang, K Kruse, T Lu, J Wang - Reviews of Modern Physics, 2019 - APS
Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions

YC Lu, X Yao, JS Crystal, YF Li, M El-Gamil… - Clinical Cancer …, 2014 - AACR
Purpose: Cancer immunotherapy with adoptive transfer of tumor-infiltrating lymphocytes
(TIL) represents an effective treatment for patients with metastatic melanoma, with the …

Motor proteins

HL Sweeney, ELF Holzbaur - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Myosin motors power movements on actin filaments, whereas dynein and kinesin motors
power movements on microtubules. The mechanisms of these motor proteins differ, but, in …

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

TU Mayer, TM Kapoor, SJ Haggarty, RW King… - Science, 1999 - science.org
Small molecules that perturb specific protein functions are valuable tools for dissecting
complex processes in mammalian cells. A combination of two phenotype-based screens …

Structural insights into microtubule function

E Nogales - Annual review of biophysics and biomolecular …, 2001 - annualreviews.org
▪ Abstract Microtubules are polymers that are essential for, among other functions, cell
transport and cell division in all eukaryotes. The regulation of the microtubule system …