The isolation of phlorizin from the bark of an apple tree in 1835 led to a flurry of research on
its inhibitory effect on glucose transporters in the intestine and kidney. Using phlorizin as a …

Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

Electrospinning-based wound dressings have multiple functions such as antibacterial, anti-
inflammatory, and therapeutic, and are important in skin wound care. Herein, we designed a …

Aging is an inevitable and complicated process involving many physiological changes.
Screening of natural biologically active anti-aging substances is a current research hotspot …

Background: Parkinson's disease (PD) is an age-related progressive multifactorial,
neurodegenerative disease. The autophagy and Keap1-Nrf2 axis system are both …

Abstract Background Doxorubicin (Dox), a chemotherapeutic agent known for its efficacy,
has been associated with the development of severe cardiotoxicity, commonly referred to as …

Ampelopsis grossedentata (vine tea) has been used as a detoxifying beverage in China for
centuries. To systematically identify its bioactive compounds, the study adopted standards …

Objectives Phloretin is ubiquitous in apples (Malus domestica) and other fruits and has
potential antidiabetic properties. Considering the preclinical potential of phloretin, its …

Flower color is the most important ornamental character trait of Malus species. The study
aimed to clarify the roles of phenolic compounds and compositions in the petal color change …

Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is
involved in the pathogenesis of diabetes-associated kidney diseases. The purpose of this …