Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen,
plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators …

The fibrinolytic system dissolves fibrin and maintains vascular patency. Recent advances in
imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of …

In order for invasive pathogens to migrate beyond the site of infection, host physiological
barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin …

The mature form of the zymogen, human plasminogen (HPlg), contains 791 amino acids
present in a single polypeptide chain. The fibrinolytic enzyme, human plasmin (HPlm), is …

Background Leptospirosis is a multisystem disease caused by pathogenic strains of the
genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to …

Revised Manuscript Received April 21, 1992 abstract: In a previous study, it was shown that
fibrin fragment E-2 selectively promotes the activation of plasminogen by pro-urokinase (pro …

Areview of the literature of plasminogen (Pg) and plasmin (Pm) encompasses many fields of
research. Studies of physical biochemistry, enzyme kinetics and mechanism, enzyme …

The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which
works promptly on vascular injury and tissue damage. The rapid response is generated by …

Background Polyamidoamine (PAMAM) dendrimers are a new class of monodisperse
polymers that are used for drug delivery in systemic administrations. The influence of …

The X-ray crystal structure of a complex of a modified recombinant kringle-2 domain of
human plasminogen, K2Pg [C4G/E56D/L72Y](mK2Pg), containing an upregulated lysine …