Osteogenesis imperfecta (OI) is an uncommon genetic disorder characterized by shortness
of stature, hearing loss, poor bone mass, recurrent fractures, and skeletal abnormalities …

Pulmonary fibrosis is a fatal and chronic lung disease that is characterized by accumulation
of thickened scar in the lungs and impairment of gas exchange. The cases with unknown …

Growth Factors have been evaluated as therapeutic targets for the treatment of a broad
spectrum of diseases. Because they are proteins with pleiotropic effects, the quest to …

Phenotypic drug discovery (PDD) continues to fuel the research and development pipelines
with first-in-class therapeutic modalities, but success rates critically depend on the quality of …

Zika virus (ZIKV) infection results in an increased risk of spontaneous abortion and poor
intrauterine growth although the underlying mechanisms remain undetermined. Little is …

Morphogenic signaling pathways govern embryonic development and tissue homeostasis
on the cellular level. Precise control of such signaling events paves the way for innovative …

Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In
animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to …

The bone morphogenetic protein (BMP) pathway is highly conserved and plays central roles
in health and disease. The quality and quantity of its signaling outputs are regulated at …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by
exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are …

Background The BMP signaling pathway plays a key role in growth, differentiation and
patterning during neural development. Recent work on the generation of a self-organization …