Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy
Y Wang, J Du, Z Gao, H Sun, M Mei, Y Wang… - British journal of …, 2023 - nature.com
Immune checkpoint blockade therapy targeting programmed cell death protein 1 (PD-1) has
revolutionized the landscape of multiple human cancer types, including head and neck …
revolutionized the landscape of multiple human cancer types, including head and neck …
Novel strategies for cancer immunotherapy: counter-immunoediting therapy
S Liu, Q Sun, X Ren - Journal of Hematology & Oncology, 2023 - Springer
The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …
especially the application of immune checkpoint inhibitors in clinical practice. Although …
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis
H Yang, Q Zhang, M Xu, L Wang, X Chen, Y Feng, Y Li… - Molecular Cancer, 2020 - Springer
Background The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights
the need for novel strategies against this disease. Our previous study suggested the …
the need for novel strategies against this disease. Our previous study suggested the …
The immune landscape of prostate cancer and nomination of PD-L2 as a potential therapeutic target
SG Zhao, J Lehrer, SL Chang, R Das… - JNCI: Journal of the …, 2019 - academic.oup.com
Background Immunotherapy has been less successful in treating prostate cancer than other
solid tumors. We sought to better understand the immune landscape in prostate cancer and …
solid tumors. We sought to better understand the immune landscape in prostate cancer and …
Cancer cell-intrinsic PD-1 and implications in combinatorial immunotherapy
H Yao, H Wang, C Li, JY Fang, J Xu - Frontiers in immunology, 2018 - frontiersin.org
Programmed death 1 (PD-1) and its two natural ligands PD-L1 and PD-L2 are responsible
for delivering inhibitory signals that regulate the balance between T cell activation …
for delivering inhibitory signals that regulate the balance between T cell activation …
Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status
The presence of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue has
been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor …
been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor …
Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …
[HTML][HTML] Identification and validation of a prognostic risk-scoring model based on sphingolipid metabolism-associated cluster in colon adenocarcinoma
Q Yuan, W Zhang, W Shang - Frontiers in Endocrinology, 2022 - frontiersin.org
Colon adenocarcinoma (COAD) is the primary factor responsible for cancer-related
mortalities in western countries, and its development and progression are affected by altered …
mortalities in western countries, and its development and progression are affected by altered …
[HTML][HTML] Characterization of spatial distribution of tumor-infiltrating CD8+ T cells refines their prognostic utility for pancreatic cancer survival
Y Masugi, T Abe, A Ueno, Y Fujii-Nishimura, H Ojima… - Modern pathology, 2019 - Elsevier
The abundance of cytotoxic T-cell infiltrates has important implications for patient outcome
and therapeutic design for pancreatic ductal adenocarcinoma. However, intratumoral …
and therapeutic design for pancreatic ductal adenocarcinoma. However, intratumoral …
[HTML][HTML] Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?
C Solinas, M Aiello, E Rozali, M Lambertini… - Translational …, 2020 - Elsevier
Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell
death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells …
death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells …