Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

Social isolation and loneliness are serious yet underappreciated public health risks that
affect a significant portion of the older adult population. Approximately one-quarter of …

The human social brain is complex. Current knowledge fails to define the neurobiological
processes underlying social behaviour involving the (patho-) physiological mechanisms that …

Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

Behavioural and psychological symptoms of dementia (BPSD) occur in most patients with
dementia. They cause great suffering in patients and caregivers, sometimes more so than …

Introduction Apathy is common in neurocognitive disorders (NCD) but NCD‐specific
diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials …

Background: Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation,
and hallucinations, are frequent in Alzheimer's disease (AD) and their prevalence tends to …

Objective To compare the utility of the Mild Behavioral Impairment-Checklist (MBI-C) and
Neuropsychiatric Inventory Questionnaire (NPI-Q) to capture NPS in subjective cognitive …

Background: Neuropsychiatric symptoms (NPS) are non-cognitive, behavioral, or psychiatric
symptoms, common in mild cognitive impairment (MCI) and associated with a higher risk of …