Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …

Food intake profoundly affects systemic physiology. A large body of evidence has indicated
a link between food intake and circadian rhythms, and~ 24‐h cycles are deemed essential …

Background Comparisons of the gut microbiome of lean and obese humans have revealed
that obesity is associated with the gut microbiome plus changes in numerous environmental …

Background and aims Atherosclerosis (AS) is one of the leading causes of cardiovascular
diseases. Studies have revealed critical roles of microRNAs (miRNAs) in the progression of …

The liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm
of genes involved in lipid metabolism is also disturbed. Although the link between …

Osteoarthritis (OA) is characterized by cartilage destruction, chronic inflammation, and local
pain. Evidence showed that retinoic acid receptor-related orphan receptor-α (RORα) is …

Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear
receptor family and functions as a transcriptional activator in response to circadian changes …

Background & Aims Hypoxia inducible factors (HIFs) are a hallmark of inflammation and are
key regulators of hepatic immunity and metabolism, yet their role in HBV replication is poorly …