Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry has been
successfully used to investigate a plethora of protein-related questions. The method, which …

The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority
of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR …

“Footprinting” refers to assays that examine ligand binding and conformational changes by
determining the solvent accessibility of the backbone, bases, or side chain structures of …

Targeted cancer therapies, which act on specific cancer-associated molecular targets, are
predominantly inhibitors of oncogenic kinases. While these drugs have achieved some …

Structural water molecules may act as prosthetic groups indispensable for proper protein
function. In the case of allosteric activation of G protein-coupled receptors (GPCRs), water …

Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise
worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host …

Chemokines drive cell migration through their interactions with seven-transmembrane (7TM)
chemokine receptors on cell surfaces. The atypical chemokine receptor 3 (ACKR3) binds …

The proton gradient is a principal energy source for respiration-dependent active transport,
but the structural mechanisms of proton-coupled transport processes are poorly understood …

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such,
tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential …