Recent work has revealed that the neural activity patterns correlated with sensation,
cognition, and action often are not stable and instead undergo large scale changes over …

During recent years, the preclinical stage of Alzheimer's disease (AD) has become a major
focus of research. Continued failures in clinical trials and the realization that early …

Neuronal representations change as associations are learned between sensory stimuli and
behavioral actions. However, it is poorly understood whether representations for learned …

Ca 2+ imaging techniques permit time-lapse recordings of neuronal activity from large
populations over weeks. However, without identifying the same neurons across imaging …

To produce consistent sensory perception, neurons must maintain stable representations of
sensory input. However, neurons in many regions exhibit progressive drift across days …

Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives
rise to balanced network dynamics is unknown. Here, we continuously monitored the …

The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Recent experiments demonstrate substantial volatility of excitatory connectivity in the
absence of any learning. This challenges the hypothesis that stable synaptic connections …