Background Skeletal muscles express a highly specialized proteome that allows the
metabolism of energy sources to mediate myofiber contraction. This muscle-specific …

In a forward genetic approach to identify novel genes for congenital muscle diseases, a
zebrafish mutant, designated patchytail, was identified that exhibits degenerating muscle …

Mutations in the δ-sarcoglycan gene cause limb-girdle muscular dystrophy 2F (LGMD2F), an
autosomal recessive disease that causes progressive weakness and wasting of the proximal …

Duchenne muscular dystrophy (DMD) is a lethal X-linked disease caused by the absence of
functional dystrophin. Abnormal excitation-contraction (EC) coupling has been reported in …

The spatiotemporal properties of the Ca2+-release process in skeletal muscle fibers from
normal and mdx fibers were determined using the confocal-spot detection technique. The …

The dystrophin-associated protein complex (DAPC) is a multimeric complex that links the
extracellular matrix to the actin cytoskeleton, and in some cases dystrophin can be …

Sarcoglycans (SGs) and sarcospan (SSPN) are transmembrane proteins of the dystrophin-
glycoprotein complex. Mutations in the genes encoding SGs cause many inherited forms of …

Background Sarcospan (SSPN) is a transmembrane protein that interacts with the
sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex …

BACKGROUND: δ-Sarcoglycan (δ-SG) knockout (KO) mice develop skeletal muscle
histopathological alterations similar to those in humans with limb muscular dystrophy …

Limb-girdle muscular dystrophy-2F (LGMD-2F) is an incurable degenerative muscle
disorder caused by a mutation in the sarcoglycan-δ (SGδ)-encoding gene (SGCD in …