Drug repurposing by tumor tissue editing
The combinatory use of drugs for systemic cancer therapy commonly aims at the direct
elimination of tumor cells through induction of apoptosis. An alternative approach becomes …
elimination of tumor cells through induction of apoptosis. An alternative approach becomes …
Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns
Follicular lymphoma (FL) accounts for∼ 20% of all new lymphoma cases. Increases in
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
cytological grade are a feature of the clinical progression of this malignancy, and eventual …
Proteomics identifies apoptotic markers as predictors of histological transformation in patients with follicular lymphoma
MBH Enemark, K Wolter, AJ Campbell… - Blood …, 2023 - ashpublications.org
Follicular lymphoma (FL) is an indolent lymphoma with a generally favorable prognosis.
However, histological transformation (HT) to a more aggressive disease leads to markedly …
However, histological transformation (HT) to a more aggressive disease leads to markedly …
[HTML][HTML] Molecular Biomarkers in Prediction of High-Grade Transformation and Outcome in Patients with Follicular Lymphoma: A Comprehensive Systemic Review
MH Enemark, JK Hemmingsen, ML Jensen… - International Journal of …, 2024 - mdpi.com
Follicular lymphoma (FL) is the most prevalent indolent B-cell lymphoma entity, often
characterized by the t (14; 18) BCL2-IGH translocation. The malignancy represents a …
characterized by the t (14; 18) BCL2-IGH translocation. The malignancy represents a …
Differential tumor protein expression at follicular lymphoma diagnosis reveals dysregulation of key molecular pathways associated with histological transformation
MH Enemark, K Wolter, TE Hybel, MD Andersen… - Scientific Reports, 2024 - nature.com
Follicular lymphoma (FL) is the most common low-grade lymphoma. Despite its indolent
nature, FL carries an inherent risk of histological transformation (HT) to a more aggressive …
nature, FL carries an inherent risk of histological transformation (HT) to a more aggressive …
[HTML][HTML] Anlotinib suppresses the DNA damage response by disrupting SETD1A and inducing p53-dependent apoptosis in Transformed Follicular Lymphoma
X Zhuang, J Yao, X Li, Y Jiang, M Zhong… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
Purpose: The high tumor mutational burden (TMB) of transformed follicular lymphoma (tFL)
leads to tumor heterogeneity and poor prognosis in follicular lymphoma, in which …
leads to tumor heterogeneity and poor prognosis in follicular lymphoma, in which …
[HTML][HTML] Impact of the Immune Landscape in Follicular Lymphoma: Insights into Histological Transformation in the Rituximab Era
MH Enemark, ML Jensen, MD Andersen, TL Plesner… - Cancers, 2024 - mdpi.com
Background: Follicular lymphoma (FL) presents significant clinical heterogeneity, with some
patients experiencing transformation into an aggressive disease, a key contributor to FL …
patients experiencing transformation into an aggressive disease, a key contributor to FL …
Tumor-tissue expression of the hyaluronic acid receptor RHAMM predicts histological transformation in follicular lymphoma patients
MB Enemark, TE Hybel, C Madsen, KL Lauridsen… - Cancers, 2022 - mdpi.com
Simple Summary Histological transformation remains the leading cause of death in patients
diagnosed with follicular lymphoma (FL). To date, no clinical nor biological biomarkers have …
diagnosed with follicular lymphoma (FL). To date, no clinical nor biological biomarkers have …
[HTML][HTML] Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma
J Arzuaga-Mendez, M Lopez-Santillan… - Critical Reviews in …, 2021 - Elsevier
Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma and usually
presents as an indolent disease. However, some patients present poor outcomes, and FL …
presents as an indolent disease. However, some patients present poor outcomes, and FL …