Cardiovascular disease remains the leading cause of disease burden globally, which
underlies the continuing need to identify new complementary targets for prevention. Over the …

Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

It is unclear to what extent poor social relationships are related to the development of
dementia. A comprehensive systematic literature search identified 19 longitudinal cohort …

The role of psychosocial work stress as a risk factor for chronic disease has been the subject
of considerable debate. Many researchers argue in support of a causal connection while …

Background The associations of social isolation and loneliness with premature mortality are
well known, but the risk factors linking them remain unclear. We sought to identify risk factors …

Background—Although prospective studies, systematic reviews, and meta-analyses have
documented an association between depression and increased morbidity and mortality in a …

Kritische Lebensereignisse gehören zum Erfahrungshorizont fast aller Menschen. Es gilt zu
präzisieren, was Ereignisse als kritisch ausweist und welchen Platz sie jeweils im Leben …

Research examining the relationship between work stress and well-being has flourished
over the past 20 years. At the same time, research on physiological stress processes has …