Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic
cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …

Background Adipose tissue-derived adipokines are involved in various crosstalk between
adipose tissue and other organs. Omentin1, a novel adipokine, exerts vital roles in the …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Diabetic cardiomyopathy (DCM) is associated with oxidative stress and augmented
inflammation in the heart. Neuraminidases (NEU) 1 has initially been described as a …

Abstract Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism
and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in
mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest …