Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

All pharmaceutical products contain organic molecules; the source may be a natural product
or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry …

In biology-oriented synthesis the underlying scaffold classes of natural products selected in
evolution are used to define biologically relevant starting points in chemical structure space …

For scientists to gain a better understanding of nature, biological research is greatly aided by
small-molecule modulators that perturb protein activity without fundamentally altering the …

Fragment-based ligand and drug discovery predominantly employs sp 2-rich compounds
covering well-explored regions of chemical space. Despite the ease with which such …

The Diels–Alder reaction is probably the most powerful technology in the synthetic repertoire
for single-step constructions of complex chiral molecules. The synthetic power of this …

Affinity selection-mass spectrometry (AS-MS) is a high-throughput screening (HTS)
technique for drug discovery that enables rapid screening of large collections of compounds …

Covering: 2008–2010 This report describes the recent applications of hypervalent iodine
reagents in the total synthesis of natural products. The large diversity of high-yielding and …

Covering: 1986 to 2020 Natural products are an enduring source of chemical information
useful for probing biologically relevant chemical space. Toward gathering further structure …