Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative
disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and …

For cancer immunotherapy via tumor antigen vaccination in combination with an adjuvant,
major challenges include the identification of a particular tumor antigen and efficient delivery …

Immune responses are generally divided into innate and adaptive responses, and the
efficacy of one is thought to be independent of the other. The regulation of immune …

Plasmacytoid dendritic cells (pDCs) are one of two principal subsets of human dendritic cells
(DCs). pDCs were initially identified in pathological specimens of reactive or neoplastic …

In vertebrates, the TLRs are a family of specialized immune receptors that induce protective
immune responses when they detect highly conserved pathogen-expressed molecules …

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and
by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic …

Toll-like receptors (TLR) are crucial players in the innate immune response to microbial
invaders. These receptors are expressed on immune cells, such as monocytes …

Immunostimulatory therapies that activate immune response pathways are of great interest
for overcoming the immunosuppression present in advanced tumors. Agonistic anti-CD40 …

Tumor immunotherapy has evolved from the use of crude bacterial extracts to chemically
synthesized ligands for specific immune receptors, such as Toll-like receptors (TLRs). One of …