Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …

The serrated neoplasia pathway constitutes an “alternative route” to colorectal cancer
(CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step …

The metabolic and signaling pathways regulating aggressive mesenchymal colorectal
cancer (CRC) initiation and progression through the serrated route are largely unknown …

Despite extensive research and improvements in understanding colorectal cancer (CRC), its
metastatic form continues to pose a substantial challenge, primarily owing to limited …

The intestinal barrier is mainly formed by a monolayer of epithelial cells, which forms a
physical barrier to protect the gut tissues from external insults and provides a …

It is newly revealed that collagen works as a physical barrier to tumor immune infiltration,
oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy …

Over the past decade, our understanding of the diversity of colorectal cancer has expanded
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …

Mesenchymal activation, characterized by dense stromal infiltration of immune and
mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving …

The early mechanisms of spontaneous tumor initiation that precede malignancy are largely
unknown. We show that reduced aPKC levels correlate with stem cell loss and the induction …