Exploration of oxygen-induced retinopathy model to discover new therapeutic drug targets in retinopathies
M Vähätupa, TAH Järvinen… - Frontiers in …, 2020 - frontiersin.org
Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and the
most widely used model for ischemic retinopathies, such as retinopathy of prematurity …
most widely used model for ischemic retinopathies, such as retinopathy of prematurity …
Investigational plasma kallikrein inhibitors for the treatment of diabetic macular edema: an expert assessment
AD Bhatwadekar, VS Kansara… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Plasma kallikrein is a mediator of vascular leakage and inflammation. Activation
of plasma kallikrein can induce features of diabetic macular edema (DME) in preclinical …
of plasma kallikrein can induce features of diabetic macular edema (DME) in preclinical …
Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model
P Grotegut, N Perumal, S Kuehn, A Smit… - Journal of …, 2020 - Springer
Background Previous studies noted that intravitreal injection of S100B triggered a glaucoma-
like degeneration of retina and optic nerve as well as microglia activation after 14 days. The …
like degeneration of retina and optic nerve as well as microglia activation after 14 days. The …
Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo
ZL Chen, PK Singh, K Horn, MR Calvano… - Blood …, 2023 - ashpublications.org
A dysregulated plasma contact system is involved in various pathological conditions, such
as hereditary angioedema, Alzheimer disease, and sepsis. We previously showed that the …
as hereditary angioedema, Alzheimer disease, and sepsis. We previously showed that the …
Silencing of YAP attenuates pericyte‐myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
Y Xu, Y Feng, R Zou, F Yuan… - Cell Biology …, 2022 - Wiley Online Library
Age‐related macular degeneration (AMD) is the main reason of irreversible vision loss in the
elderly. The subretinal fibrosis subsequent to choroidal neovascularization (CNV) is an …
elderly. The subretinal fibrosis subsequent to choroidal neovascularization (CNV) is an …
Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
ZL Chen, PK Singh, K Horn, S Strickland… - Blood …, 2022 - ashpublications.org
Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of
dementia. Vascular abnormalities and neuroinflammation play roles in AD pathogenesis …
dementia. Vascular abnormalities and neuroinflammation play roles in AD pathogenesis …
Targeting plasma kallikrein with a novel bicyclic peptide inhibitor (THR-149) reduces retinal thickening in a diabetic rat model
T Van Bergen, TT Hu, K Little… - … & visual science, 2021 - iovs.arvojournals.org
Purpose: To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on
preventing key pathologies associated with diabetic macular edema (DME) in a rat model …
preventing key pathologies associated with diabetic macular edema (DME) in a rat model …