The discovery of Mas-related G protein-coupled receptors (Mrgprs) has opened a
compelling chapter in our understanding of immunity and sensory biology. This family of …

Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …

Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of
itch is mediated through a subclass of primary afferent sensory neurons, termed …

Affective touch—a slow, gentle, and pleasant form of touch—activates a different neural
network than which is activated during discriminative touch in humans. Affective touch …

The PIEZO2 ion channel is critical for transducing light touch into neural signals but is not
considered necessary for transducing acute pain in humans. Here, we discovered an …

Splicing is a posttranscriptional RNA processing mechanism that enhances genomic
complexity by creating multiple isoforms from the same gene. We aimed to characterize the …

Touch perception is enabled by mechanically activated ion channels, the opening of which
excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as …