Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design

KC Ferrell, MD Johansen, JA Triccas… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group,
responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise …

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

MJ Shepherd, T Fu, NE Harrington, A Kottara… - Nature Reviews …, 2024 - nature.com
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …

[HTML][HTML] Impact of Mycobacteroides abscessus colony morphology on biofilm formation and antimicrobial resistance

AM Oschmann-Kadenbach, C Schaudinn… - International Journal of …, 2024 - Elsevier
Mycobacteroides abscessus is one of the most resistant bacteria so far known and causes
severe and hard to treat lung infections in predisposed patients such as those with Cystic …

Molecular epidemiology of Mycobacterium abscessus isolates recovered from German cystic fibrosis patients

N Wetzstein, M Diricks, TA Kohl… - Microbiology …, 2022 - Am Soc Microbiol
Infections due to Mycobacterium abscessus are a major cause of mortality and morbidity in
cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved …

Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted Mycobacterium abscessus isolates

K De, JM Belardinelli… - Proceedings of the …, 2024 - National Acad Sciences
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic
pulmonary infections in humans. One of the genes found to be under strong evolutionary …

Noncanonical mismatch repair protein NucS modulates the emergence of antibiotic resistance in Mycobacterium abscessus

R Fressatti Cardoso, I Martín-Blecua… - Microbiology …, 2022 - Am Soc Microbiol
NucS/EndoMS-dependent noncanonical mismatch repair (MMR) ensures the stability of
genomic DNA in mycobacteria and acts as a guardian of the genome by preventing the …

Clinically relevant mutations in the PhoR sensor kinase of host-adapted Mycobacterium abscessus isolates impact response to acidic pH and virulence

JM Belardinelli, D Arora, C Avanzi… - Microbiology …, 2023 - Am Soc Microbiol
Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically
infected patients to identify genes under strong evolutionary pressure during lung adaptation …

Potential opportunities and challenges for infection prevention and control for cystic fibrosis in the modern era

L Murray, L Saiman - Current Opinion in Infectious Diseases, 2022 - journals.lww.com
Potential opportunities and challenges for infection prevent... : Current Opinion in Infectious
Diseases Potential opportunities and challenges for infection prevention and control for cystic …

Microevolution, reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus

S Buenestado-Serrano, M Martínez-Lirola… - Nature …, 2024 - nature.com
Mycobacterium abscessus is an opportunistic, extensively drug-resistant non-tuberculous
mycobacterium. Few genomic studies consider its diversity in persistent infections. Our aim …

Clinical and genomic features of Mycobacterium avium complex: a multi-national European study

N Wetzstein, M Diricks, TB Anton, S Andres, M Kuhns… - Genome Medicine, 2024 - Springer
Abstract Background The Mycobacterium avium complex (MAC) comprises the most
frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently includes …