Dopamine and the brainstem locomotor networks: from lamprey to human

D Ryczko, R Dubuc - Frontiers in neuroscience, 2017 - frontiersin.org
In vertebrates, dopamine neurons are classically known to modulate locomotion via their
ascending projections to the basal ganglia that project to brainstem locomotor networks. An …

T he pedunculopontine tegmental nucleus—A functional hypothesis from the comparative literature

NK Gut, P Winn - Movement Disorders, 2016 - Wiley Online Library
We present data from animal studies showing that the pedunculopontine tegmental nucleus—
conserved through evolution, compartmentalized, and with a complex pattern of inputs and …

Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion

AM Lee, JL Hoy, A Bonci, L Wilbrecht, MP Stryker… - Neuron, 2014 - cell.com
Sensory processing is dependent upon behavioral state. In mice, locomotion is
accompanied by changes in cortical state and enhanced visual responses. Although recent …

Non-motor outcomes depend on location of neurostimulation in Parkinson's disease

JN Petry-Schmelzer, M Krause, TA Dembek, A Horn… - Brain, 2019 - academic.oup.com
Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for
patients with advanced Parkinson's disease improving quality of life, motor symptoms and …

Proceedings of the seventh annual deep brain stimulation think tank: advances in neurophysiology, adaptive DBS, virtual reality, neuroethics and technology

A Ramirez-Zamora, J Giordano, A Gunduz… - Frontiers in human …, 2020 - frontiersin.org
The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of
2019 addressed the most current:(1) use and utility of complex neurophysiological signals …

The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics

M Onofrj, M Russo, S Delli Pizzi, D De Gregorio… - Translational …, 2023 - nature.com
The PD-DLB psychosis complex found in Parkinson's disease (PD) and Dementia with Lewy
Bodies (DLB) includes hallucinations, Somatic Symptom/Functional Disorders, and …

The integrative role of the pedunculopontine nucleus in human gait

B Lau, ML Welter, H Belaid, S Fernandez Vidal… - Brain, 2015 - academic.oup.com
The brainstem pedunculopontine nucleus has a likely, although unclear, role in gait control,
and is a potential deep brain stimulation target for treating resistant gait disorders. These …

[HTML][HTML] Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson's disease

HS Dafsari, MG dos Santos Ghilardi… - Brain stimulation, 2020 - Elsevier
Background Subthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve
quality of life, motor, and nonmotor symptoms (NMS) in advanced Parkinson's disease (PD) …

Rotigotine may improve sleep architecture in Parkinson's disease: a double-blind, randomized, placebo-controlled polysomnographic study

M Pierantozzi, F Placidi, C Liguori, M Albanese… - Sleep medicine, 2016 - Elsevier
Abstract Background/Objectives Growing evidence demonstrates that in Parkinson's
Disease (PD) sleep disturbances are frequent and difficult to treat. Since the efficacy of …

Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism

NK Gut, P Winn - Journal of Neuroscience, 2015 - Soc Neuroscience
The pedunculopontine tegmental nucleus (PPTg) has been proposed as a target for deep
brain stimulation (DBS) in parkinsonian patients, particularly for symptoms such as gait and …