Accurate in silico prediction of protein–ligand binding affinities has been a primary objective
of structure-based drug design for decades due to the putative value it would bring to the …

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

We reported a selective semihydrogenation (deuteration) of numerous terminal and internal
alkynes using H2O (D2O) as the H (D) source over a Pd‐P alloy cathode at a lower …

Stereochemically defined C-glycosides are prized for their biological activity. Developing a
catalytic method that comprises non-precious metals to synthesize these C-glycosides …

The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Despite the resistance of triple-negative breast cancer (TNBC) to targeted hormone therapy,
the discovery of azobenzene combretastatin A4 (Azo-CA4) provides therapeutic …