Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22
(PTPN22) gene is associated with increased susceptibility to autoimmunity and infection …

Toll‐like receptors (TLR) are transmembrane pattern recognition receptors that recognize
microbial ligands and signal for production of inflammatory cytokines and type I interferon in …

Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of
leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22 …

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. IRGM1 is an
important protein in the innate immune response against intracellular pathogens by …

Background: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine
phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for …

Previous studies identified the functional polymorphism 1858C/T in the gene PTPN22 in
association with several autoimmune diseases and with resistance to tuberculosis (TB). This …

Tuberculosis (TB) is the leading cause of death due to an infectious disease worldwide,
particularly in developing countries. A series of candidate genes have been suggested to be …

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7
receptor is an ATP-gated cation channel expressed in immune cells, and it influences the …

In this study we aimed to evaluate the possible association of PTPN 22 rs2476601 as well
as epidermal growth factor receptor (EGFR) rs17337023 gene polymorphism and …

Abstract The rs2476601 (R620W, C1858T) polymorphism in PTPN22 gene has been
repeatedly reported to be associated with rheumatoid arthritis (RA). The rs 2476601 is …