The establishment and maintenance of epithelial cell-cell junctions is crucially important to
regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls …

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against
desmosomal cadherins, but the precise mechanisms are in part a matter of controversial …

Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Cell–cell adhesions are necessary for structural integrity and barrier formation of the
epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of …

Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous
diseases of the mucosae and/or skin associated with autoantibodies directed against …

Desmosomes provide strong intercellular cohesion essential for the integrity of cells and
tissues exposed to continuous mechanical stress. For desmosome assembly, constitutively …

The single pass, transmembrane proteins of the cadherin family have been appreciated as
important proteins that regulate intercellular adhesion. In addition to this critical function …

Desmosomes are adhering junctions present in all cells of simple and complex epithelia.
They are most abundant in cells of tissues subjected to extensive mechanical stress such as …

The Hippo pathway is an evolutionarily conserved pathway that serves to promote cell death
and differentiation while inhibiting cellular proliferation across species. The downstream …