How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects
J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
Spotlight on genetic kidney diseases: A call for drug delivery and nanomedicine solutions
N Trac, A Ashraf, J Giblin, S Prakash, S Mitragotri… - ACS …, 2023 - ACS Publications
Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …
Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes
N Chaudhary, AN Newby, ML Arral… - Proceedings of the …, 2024 - National Acad Sciences
Treating pregnancy-related disorders is exceptionally challenging because the threat of
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …
Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta
During healthy pregnancy, the placenta develops to allow for exchange of nutrients and
oxygen between the mother and the fetus. However, placental dysregulation can lead to …
oxygen between the mother and the fetus. However, placental dysregulation can lead to …
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
Congenital disorders resulting in pathological protein deficiencies are most often treated
postnatally with protein or enzyme replacement therapies. However, treatment of these …
postnatally with protein or enzyme replacement therapies. However, treatment of these …
Delivery technologies for women's health applications
The treatment of women's health-related conditions, including reproductive tract and
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …
[HTML][HTML] Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for
vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA …
vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA …
Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction
J Cheng, S Zhang, C Li, K Li, X Jia, Q Wei, H Qi… - Nature …, 2022 - nature.com
There is still unmet demand for effective, safe, and patient-friendly anti-thrombotics to treat
deep vein thrombosis (DVT) during pregnancy. Here we first engineer a bioactive …
deep vein thrombosis (DVT) during pregnancy. Here we first engineer a bioactive …
Nanotechnology in healthcare, and its safety and environmental risks
X Ma, Y Tian, R Yang, H Wang, LW Allahou… - Journal of …, 2024 - Springer
Nanotechnology holds immense promise in revolutionising healthcare, offering
unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating …
unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating …
Rational design of nanomedicine for placental disorders: birthing a new era in women's reproductive health
The placenta is a transient organ that forms during pregnancy and acts as a biological
barrier, mediating exchange between maternal and fetal circulation. Placental disorders …
barrier, mediating exchange between maternal and fetal circulation. Placental disorders …