How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Spotlight on genetic kidney diseases: A call for drug delivery and nanomedicine solutions

N Trac, A Ashraf, J Giblin, S Prakash, S Mitragotri… - ACS …, 2023 - ACS Publications
Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …

Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes

N Chaudhary, AN Newby, ML Arral… - Proceedings of the …, 2024 - National Acad Sciences
Treating pregnancy-related disorders is exceptionally challenging because the threat of
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …

Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta

HC Safford, KL Swingle, HC Geisler, AG Hamilton… - Small, 2024 - Wiley Online Library
During healthy pregnancy, the placenta develops to allow for exchange of nutrients and
oxygen between the mother and the fetus. However, placental dysregulation can lead to …

Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery

KL Swingle, MM Billingsley, SK Bose, B White… - Journal of Controlled …, 2022 - Elsevier
Congenital disorders resulting in pathological protein deficiencies are most often treated
postnatally with protein or enzyme replacement therapies. However, treatment of these …

Delivery technologies for women's health applications

KL Swingle, AS Ricciardi, WH Peranteau… - Nature Reviews …, 2023 - nature.com
The treatment of women's health-related conditions, including reproductive tract and
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …

[HTML][HTML] Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach

RE Young, KM Nelson, SI Hofbauer, T Vijayakumar… - Bioactive Materials, 2024 - Elsevier
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for
vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA …

Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction

J Cheng, S Zhang, C Li, K Li, X Jia, Q Wei, H Qi… - Nature …, 2022 - nature.com
There is still unmet demand for effective, safe, and patient-friendly anti-thrombotics to treat
deep vein thrombosis (DVT) during pregnancy. Here we first engineer a bioactive …

Nanotechnology in healthcare, and its safety and environmental risks

X Ma, Y Tian, R Yang, H Wang, LW Allahou… - Journal of …, 2024 - Springer
Nanotechnology holds immense promise in revolutionising healthcare, offering
unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating …

Rational design of nanomedicine for placental disorders: birthing a new era in women's reproductive health

HC Geisler, HC Safford, MJ Mitchell - Small, 2024 - Wiley Online Library
The placenta is a transient organ that forms during pregnancy and acts as a biological
barrier, mediating exchange between maternal and fetal circulation. Placental disorders …