An overview on the recent advances in alternative solvents as stabilizers of proteins and enzymes

JS Almeida, EV Capela, AM Loureiro, APM Tavares… - ChemEngineering, 2022 - mdpi.com
Currently, the use of alternative solvents is increasing, namely ionic liquids (ILs) and deep
eutectic solvents (DESs) in diverse fields of knowledge, such as biochemistry, chemistry …

Hydration in deep eutectic solvents induces non-monotonic changes in the conformation and stability of proteins

A Sanchez-Fernandez, M Basic, J Xiang… - Journal of the …, 2022 - ACS Publications
The preservation of labile biomolecules presents a major challenge in chemistry, and deep
eutectic solvents (DESs) have emerged as suitable environments for this purpose. However …

Investigating biomolecules in deep eutectic solvents with molecular dynamics simulations: current state, challenges and future perspectives

JP Bittner, I Smirnova, S Jakobtorweihen - Molecules, 2024 - mdpi.com
Deep eutectic solvents (DESs) have recently gained increased attention for their potential in
biotechnological applications. DESs are binary mixtures often consisting of a hydrogen bond …

Comprehending the intermolecular interaction of JAK inhibitor fedratinib with bovine serum albumin (BSA)/human alpha-1-acid glycoprotein (HAG): Multispectral …

SL Jiang, WJ Wang, ZY Hu, RJ Zhang, JH Shi - Spectrochimica Acta Part A …, 2024 - Elsevier
The primary coverage of this paper is to investigate the molecular interaction of JAK2
inhibitor, fedratinib (FED) with BSA/HAG proteins through multispectral approaches and …

Unveiling the influence of hydrated deep eutectic solvents on the dynamics of water–soluble proteins

G Parisse, D Narzi, BD Belviso, V Capriati… - The Journal of …, 2023 - ACS Publications
Deep eutectic solvents (DESs) are mixtures of two or more pure compounds (eg, Lewis or
Brønsted acids and bases, anionic and/or cationic species) in a well-defined stoichiometric …

Stabilization of Non-Native Folds and Programmable Protein Gelation in Compositionally Designed Deep Eutectic Solvents

A Sanchez-Fernandez, JF Poon, AE Leung… - ACS …, 2024 - ACS Publications
Proteins are adjustable units from which biomaterials with designed properties can be
developed. However, non-native folded states with controlled topologies are hardly …

An innovative, low-cost and environment-friendly approach by using a deep eutectic solvent as the water substitute to minimize waste in the textile industry and for …

Z Jiang, Y Cui, G Zheng, Y Wei, Q Wang, M Zhou… - Green …, 2022 - pubs.rsc.org
With the increase in environmental protection awareness, the development of strategies to
reduce effluent and lower the cost of the chemical reagents used in the textile wetting …

Origin of structural and dynamic heterogeneity in thymol and coumarin-based hydrophobic deep eutectic solvents as revealed by molecular dynamics

A Malik, HK Kashyap - Physical Chemistry Chemical Physics, 2023 - pubs.rsc.org
Hydrophobic deep eutectic solvents (HDESs) have recently emerged as a class of water-
immiscible solvents with greener starting materials and inherent hydrophobic character …

Assessing the impact of choline chloride and benzyltrimethylammonium chloride-based deep eutectic solvents on the structure and conformational dynamics of bovine …

S Barik, A Mahapatra, N Preeyanka… - Physical Chemistry …, 2023 - pubs.rsc.org
Although deep eutectic solvents (DESs) are regarded as useful substitutes for both ionic
liquids and common organic solvents for storage and applications of biomolecules, it is still …

Protein stability in a natural deep eutectic solvent: Preferential hydration or solvent slaving?

I Gomes, N Galamba - The Journal of Chemical Physics, 2023 - pubs.aip.org
Deep eutectic solvents (DESs) emerged as potential alternative solvent media in multiple
areas, including biomolecular (cryo) preservation. Herein, we studied the stability of a small …