Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

In the 100 years since sickle cell anemia (SCA) was first described in the medical literature,
studies of its molecular and pathophysiological basis have been at the vanguard of scientific …

Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Sickle cell disease is a very variable condition, with outcomes ranging from death in
childhood to living relatively symptom free into the 8 th decade. Much of this variability is …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is a monogenic, yet highly phenotypically variable disease with
multisystem pathology. This manuscript provides an overview of many of the known …

Abstract α‐Thalassemia is one of the most important genetic modulators of sickle cell
disease (SCD). Both beneficial and detrimental effects have been described previously. We …

Sickle cell disease (SCD) is an inherited haemoglobin disorder, associated with recurrent
painful episodes, ongoing haemolytic anaemia and progressive multi-organ damage. Until …

Background Africa has the highest burden of Sickle cell disease (SCD) but there are few
large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania …

Objective: To summarize prevalence data on the neurologic complications of sickle cell
disease (SCD) in Africa. Methods: We searched EMBASE, PubMed, and African Index …