Advancements in mass spectrometry‐based proteomics have enabled experiments
encompassing hundreds of samples. While these large sample sets deliver much‐needed …

Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only
increase. To help in combating the devastating array of phenotypes associated with T2DM a …

Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …

The ability to respond to various intracellular and/or extracellular stresses allows the
organism to adapt to changing environmental conditions and drives evolution. It is now well …

Management of energy stores is critical during endurance exercise; a shift in substrate
utilization from glucose toward fat is a hallmark of trained muscle. Here we show that this key …

We previously demonstrated that the deletion of the poly (ADP-ribose) polymerase (Parp)-1
gene in mice enhances oxidative metabolism, thereby protecting against diet-induced …

INTRODUCTION Over the past two decades, continuous improvements in “omics”
technologies have driven an ever-greater capacity to define the relationships between …

Patterns of gene expression in the central nervous system are highly variable and heritable.
This genetic variation among normal individuals leads to considerable structural, functional …