An increase in centrosome number is commonly observed in cancer cells, but the role
centrosome amplification plays along with how and when it occurs during cancer …

Abstract Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully
regulates centriole duplication in a spatiotemporal manner to ensure the fidelity of …

Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors
for cancer associated centrosome amplification. Increased PLK4 levels was also shown to …

Background Identification of novel molecular target (s) is important for designing newer
mechanistically driven approaches for the treatment of prostate cancer (PCa), which is one …

Triple-negative breast cancer (TNBC) surpasses other BC subtypes as the most challenging
to treat due to its lack of traditional BC biomarkers. Nearly 30% of TNBC patients express the …

Eukaryotic cells utilize oxygen for different functions of cell organelles owing to cellular
survival. A balanced oxygen homeostasis is an essential requirement to maintain the …

Abstract Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several
evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure …

Pancreatic cancer is the seventh leading cause of cancer-related deaths, and chemotherapy
is one of the most important treatments for pancreatic cancer. Unfortunately, pancreatic …

High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and
extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a …

Abstract Polo‑like kinase 4 (PLK4) promotes tumorigenesis and is associated with the
prognosis of several solid tumors, while its clinical role in patients with renal cell carcinoma …