Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …

Plasmacytoid dendritic cells (pDCs) are one of two principal subsets of human dendritic cells
(DCs). pDCs were initially identified in pathological specimens of reactive or neoplastic …

Plasmacytoid dendritic cells (PDCs) are key effectors in host innate immunity and
orchestrate adaptive immune responses. CpG oligodeoxynucleotides (ODN) have potent …

Successful blood and marrow transplant (BMT), both autologous and allogeneic, requires
the infusion of a sufficient number of hematopoietic progenitor/stem cells (HPCs) capable of …

Flow cytometry has evolved over the past 30 y from a niche laboratory technique to a routine
tool used by clinical pathologists and immunologists for diagnosis and monitoring of patients …

Hematopoietic stem cell transplantation is the only curative treatment for many malignant
hematologic diseases, with an often critical graft-versus-leukemia effect. Despite …

Despite improvements in the practice of allogeneic hematopoietic stem cell transplantation
(HCT) over the last 25 years, chronic graft-versus-host disease (GVHD) remains a …

In 1958 Lennert and Remmele drew attention to a cell type present in the interfollicular
areas of human lymph nodes that they described (on the basis of pure morphology) as a …

Type 1 interferon–producing cells (IPCs), also known as plasmacytoid dendritic cell (DC)
precursors, represent the key effectors in antiviral innate immunity and triggers for adaptive …

Donor lymphocyte infusion (DLI) using unstimulated leukapheresis is one of the most
effective treatment strategies for patients with hematological malignancies; its graft-versus …