Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes
remain dismal. Developing successful treatments for glioma requires faithful in vivo disease …

Glioma, the most common primary brain tumor in adults, can be difficult to discern
radiologically from other brain lesions, which affects surgical planning and follow-up …

Purpose Gliomas, the most common primary brain tumours, have recently been re-classified
incorporating molecular aspects with important clinical, prognostic, and predictive …

Background This translational study explores multi-tracer PET imaging for the non-invasive
detection of the IDH1 mutation which is a positive prognostic factor in glioma. Methods U87 …

Background. The prognosis of IDH1‐mutant glioma is significantly better than that of wild‐
type glioma, and the preoperative identification of IDH mutations in glioma is essential for …

Models for human gliomas prove critical not only to advancing our understanding of glioma
biology but also to facilitate the development of therapeutic modalities. Specifically, creating …

The physiological mechanism induced by the isocitrate dehydrogenase 1 (IDH1) mutation,
associated with better treatment response in gliomas, remains unknown. The aim of this …

Orthotopic transplantation of glioblastoma cells in the brain of laboratory mice is a common
animal model for studying brain tumors. It was shown that 1H magnetic resonance …

Purpose Currently, there remains a scarcity of established preoperative tests to accurately
predict the isocitrate dehydrogenase (IDH) mutation status in clinical scenarios, with limited …