The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

S Chakraborty, S Kaur, S Guha, SK Batra - Biochimica et Biophysica Acta …, 2012 - Elsevier
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

[PDF][PDF] Maternal high‐fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

KD Bruce, FR Cagampang, M Argenton, J Zhang… - …, 2009 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) describes an increasingly prevalent spectrum of
liver disorders associated with obesity and metabolic syndrome. It is uncertain why steatosis …

Biological functions and therapeutic potential of lipocalin 2 in cancer

GS Santiago-Sánchez, V Pita-Grisanti… - International journal of …, 2020 - mdpi.com
Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including
transporting hydrophobic ligands across cell membranes, modulating immune responses …

Lipocalin-2 silencing suppresses inflammation and oxidative stress of acute respiratory distress syndrome by ferroptosis via inhibition of MAPK/ERK pathway in …

X Wang, C Zhang, N Zou, Q Chen, C Wang… - …, 2022 - Taylor & Francis
Neonatal acute respiratory distress syndrome (ARDS) has high morbidity and mortality rates
worldwide, but there is a lack of pharmacologic treatment and clinical targeted therapies. In …

The origin of multiple molecular forms in urine of HNL/NGAL

L Cai, J Rubin, W Han, P Venge… - Clinical Journal of the …, 2010 - journals.lww.com
Background and objectives: Several molecular forms of human neutrophil
lipocalin/neutrophil gelatinase-associated lipocalin (HNL/NGAL), a novel biomarker for …

Iron metabolism in the pathogenesis of iron-induced kidney injury

AMF Martines, R Masereeuw, H Tjalsma… - Nature Reviews …, 2013 - nature.com
In the past 8 years, there has been renewed interest in the role of iron in both acute kidney
injury (AKI) and chronic kidney disease (CKD). In patients with kidney diseases, renal …

[HTML][HTML] Increased lipocalin-2 contributes to the pathogenesis of psoriasis by modulating neutrophil chemotaxis and cytokine secretion

S Shao, T Cao, L Jin, B Li, H Fang, J Zhang… - Journal of Investigative …, 2016 - Elsevier
Psoriasis is characterized by resistance to infections, which is regulated by antimicrobial
proteins. Whether antimicrobial proteins play a pathogenic role in psoriasis remains unclear …

Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial

M Haase, A Haase-Fielitz, R Bellomo… - Critical care …, 2009 - journals.lww.com
Objective: To test whether perioperative sodium bicarbonate infusion can attenuate
postoperative increases in serum creatinine in cardiac surgical patients. Design: Double …

[HTML][HTML] Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis

E Borkham-Kamphorst, E van de Leur… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Lipocalin-2 is expressed under pernicious conditions such as intoxication, infection,
inflammation and other forms of cellular stress. Experimental liver injury induces rapid and …