[HTML][HTML] Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours
and their resistance to treatment, and is associated with poor outcomes for patients with …
and their resistance to treatment, and is associated with poor outcomes for patients with …
[HTML][HTML] Extrachromosomal circular DNA in colorectal cancer: biogenesis, function and potential as therapeutic target
Y Chen, Q Qiu, J She, J Yu - Oncogene, 2023 - nature.com
Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery
more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly …
more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly …
[HTML][HTML] Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
R Chamorro González, T Conrad, MC Stöber, R Xu… - Nature Genetics, 2023 - nature.com
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
[HTML][HTML] Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
[HTML][HTML] Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma
Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of∼ 15
months. Targeted approaches have not been successful in this tumor type due to the large …
months. Targeted approaches have not been successful in this tumor type due to the large …
Extrachromosomal DNA: Biogenesis and Functions in Cancer
In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …
Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance
The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not
found in normal cells. Analysis of clinical samples reveal they are common in most cancers …
found in normal cells. Analysis of clinical samples reveal they are common in most cancers …
[HTML][HTML] Etiology of super-enhancer reprogramming and activation in cancer
RW Zhou, RE Parsons - Epigenetics & Chromatin, 2023 - Springer
Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes
critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer …
critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer …
[HTML][HTML] Life in plastic, it's fantastic! How Leishmania exploit genome instability to shape gene expression
JA Black, JL Reis-Cunha, AK Cruz… - Frontiers in cellular and …, 2023 - frontiersin.org
Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …