Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

[HTML][HTML] A review of EEG signal features and their application in driver drowsiness detection systems

I Stancin, M Cifrek, A Jovic - Sensors, 2021 - mdpi.com
Detecting drowsiness in drivers, especially multi-level drowsiness, is a difficult problem that
is often approached using neurophysiological signals as the basis for building a reliable …

[HTML][HTML] Sleep and human aging

BA Mander, JR Winer, MP Walker - Neuron, 2017 - cell.com
Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity
and quality occur as we age, and are there functional consequences? What are the …

[HTML][HTML] Old brains come uncoupled in sleep: slow wave-spindle synchrony, brain atrophy, and forgetting

RF Helfrich, BA Mander, WJ Jagust, RT Knight… - Neuron, 2018 - cell.com
The coupled interaction between slow-wave oscillations and sleep spindles during non-
rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation …

Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning

G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery

T Atkin, S Comai, G Gobbi - Pharmacological reviews, 2018 - ASPET
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

[HTML][HTML] Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource

SM Purcell, DS Manoach, C Demanuele… - Nature …, 2017 - nature.com
Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-
rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning …

Oscillating circuitries in the sleeping brain

AR Adamantidis, C Gutierrez Herrera… - Nature Reviews …, 2019 - nature.com
Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

[HTML][HTML] About sleep's role in memory

B Rasch, J Born - Physiological reviews, 2013 - journals.physiology.org
Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

[HTML][HTML] Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans

RF Helfrich, JD Lendner, BA Mander, H Guillen… - Nature …, 2019 - nature.com
How are memories transferred from short-term to long-term storage? Systems-level memory
consolidation is thought to be dependent on the coordinated interplay of cortical slow waves …